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8-K
FIBROCELL SCIENCE, INC. filed this Form 8-K on 02/05/2018
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Localized Scleroderma 16 Disease Epidemiology • Excess production of collagen characterized by skin fibrosis and scars • Focus on moderate to severe subtypes, including linear • Thickening may extend to underlying tissue and muscle in children which may impair growth in affected limbs or forehead • Lesions appearing across joints impair motion and may be permanent • Localized Scleroderma ~160,000 sufferers US5 comprised of different sub- types  ~90,000 patients are considered moderate to severe6 Current Treatments Current treatments only address symptoms: • Systemic or topical corticosteroids • UVA light therapy • Physical therapy Photo: Reprinted from the Journal of the American Academy of Dermatology, Volume 59, Issue 3, Stéphanie Christen-Zaech, Miriam D. Hakim, F. Sule Afsar, Amy S. Paller. Pediatric morphea (localized scleroderma): Review of 136 patients, Figure 1, pp. 385-396. Copyright Sept 2008. Used with permission from Elsevier Ltd.